Overview Detailed Overview AVANCE AV with SGU OneBay/MicroBay AVANCE AV with SGU TwoBay AVANCE II with DRU OneBay/MicroBay AVANCE II with DRU TwoBay AVANCE III OneBay Cabinet AVANCE III TwoBay Cabinet List of Manuals Help

AVANCE Beginner's Level Guides and Tutorials


AVANCE Beginner's Guide

The goal of the AVANCE Beginner's Guide is to enable a relatively inexperienced user to carry out a series of basic 1-D High Resolution (HR) NMR experiments. Cholesterylacetate was chosen as an example. Both proton observe and carbon observe (with and without proton decoupling) are described. To assist the user standard parameter sets delivered with every XWIN-NMR/TopSpin software packages will be used. However, rather than simply reading in standard parameter sets, a genuine effort has been made to help the user understand the relevance of the various parameters. In particular, this manual concentrates on describing the acquisition procedure, to some extent, at the expense of processing the acquired data. This emphasis minimizes the time spent on the actual spectrometer itself, particularly in the case where relatively large numbers of undergraduate students are being trained. In this scenario processing can be easily carried out on a separate workstation using the tutorials delivered with the spectrometer documentation.

While every effort has been made to genuinely provide a step-by-step description, new users will invariably have some questions, and as such will require occasional assistance from a more experienced user. The goal of this manual is, where practicable, to enable users to work independently and acquire a basic understanding of how to operate the system. It is hoped that the time taken to train new users will be significantly reduced with the use of this manual.

The manual is currently available in the following languages for TopSpin users:


English
(version 4)
German
(version 4)
French
(version 3)
Spanish
(version 3)
Italian
(version 3)

The manual is currently available in the following languages for XWIN-NMR users:


English
German
French
Spanish
Italian

NMR 1D and 2D Experiments: Step-by-Step Tutorials

The 1D and 2D Experiments Step-by-Step Tutorials were written for AVANCE systems running TopSpin and should be used as a guide through the set up process for some experiments. The success of running the experiments in these manuals are under the assumption that all parameters have been entered in to the prosol table.

There are two tutorials available, one for basic experiments and one for advanced experiments:

1D and 2D Experiments Step-by-Step Tutorial: Basic Experiments

1D and 2D Experiments Step-by-Step Tutorial: Advanced Experiments
 

AVANCE NMR Hardware Guides

The AVANCE NMR Hardware Guides are intended to serve as introductory guides to AVANCE spectrometer hardware. They have been written primarily for operators who wish to have basic information regarding the system components and how they interact with one another. They are not intended as service guides and will in no way equip the reader to carry out any service or repairs. However there is an ever increasing desire for users to understand the underlying hardware so they can:

  • Choose the most appropriate system for their needs.
  • Make sensible decisions regarding expanding or upgrading current systems.
  • Optimize their existing system’s performance.

At a more fundamental level there is a widely held belief that as spectrometers become more and more complex the operators have less and less of an understanding of the spectrometer hardware.These guides are intended to help reverse that trend. It is also hoped that the reader will come to appreciate some of the design issues involved in modern spectrometer systems.

There are two guides available, one for AVANCE AV and AVANCE II systems, and one for the new AVANCE III systems. Currently the guides are only available in English:


AVANCE AV/II
AVANCE III

GLP Verification User Guide

Many chemical, pharmaceutical, biotech companies and laboratories must comply with regulatory requirements or are planning to organize their activity according to federal or international quality management standards. One of the best known standards is GLP, or Good Laboratory Practice.

In the U.S.A. GLP documents are issued by the Food and Drug Administration (FDA). The FDA GLP regulations are enforceable under the Federal Food, Drug and Cosmetic Act, and apply to non-clinical laboratory studies that are submitted to the FDA in support of an application for a research or marketing permit.

FDA regulations have also been taken on by the Council of the OECD countries, who then advised the corresponding health ministers to adopt GLP. Laws have then been formulated to cover this matter in each country, i.e., to regulate the way chemical substances are dealt with and with instrumentation in non-clinical laboratories.

Based on its official definition, GLP is concerned with the organizational processes and conditions under which laboratory studies are:

  • Planned
  • Performed
  • Monitored
  • Recorded
  • Reported

GLP data are intended to promote the quality and validity of test data.

The GLP Requirements User Guide provides an overview of GLP for laboratory managers (LM’s), and those people responsible in applying GLP principles to the above mentioned conditions in an environment with NMR systems.